Second-line Therapeutics for Metastatic Clear Cell Renal Carcinoma. A cancer cell is shown targeted by immune checkpoint inhibitors and antiangiogenic agents. The cancer cell is under attack by an activated T cell and the angiogenic signal for vascular growth is interrupted by inhibition of the VEGFR2 tyrosine kinase. The background shows a nephron (clear cell carcinoma originated from the proximal tubule) and a kidney with a tumor with angiogenic vessel growth.